IDOはどのようにして免疫反応に影響を及ぼすのでしょうか?
IDOの発現上昇によるT細胞の抑制機序について学ぶ
IDO1(Indoleamine 2,3-dioxygenase-1)は、トリプトファンをキヌレニンに代謝し、それによりT細胞の増殖が抑制され、制御性T細胞(Treg)の分化を誘導します。IDO1の阻害により、T細胞の機能が回復し、腫瘍微小環境へのTregの集積が減少する可能性があります。
IDOの発現上昇によるT細胞の抑制機序について学ぶ
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